Table 1. Baseline clinical characteristics of sTILs and iTILs in different TNBC groups.
| Characteristics | N (%) | P-value of sTILs | P-value of iTILs |
|---|---|---|---|
| Age (years) | |||
| ≤ 50 | 196 (46.1) | 0.002* | 0.17* |
| > 50 | 229 (53.9) | ||
| Tumor size (cm) | |||
| pT1 (0.1–2.0) | 180 (42.4) | 0.73# | 0.19# |
| pT2 (2.1–5.0) | 227 (53.4) | ||
| pT3 (>5.0) | 12 (2.8) | ||
| Unknown | 6 (1.4) | ||
| Nodal status | |||
| pN0 (0) | 263 (61.9) | 0.08# | 0.95# |
| pN1 (1–3) | 75 (17.6 ) | ||
| pN2/N3 (4+) | 63 (14.8) | ||
| Unknown | 24 (5.7) | ||
| Histological grade | |||
| 2 | 136 (32) | < 0.001* | 0.005* |
| 3 | 289 (68) | ||
| Histological type | |||
| Invasive carcinoma of | 413 (97.2) | 0.33* | 0.25* |
| no special type | |||
| Special subtype | 12 (2.8) | ||
| Local treatment | |||
| Mastectomy | 247 (59.1) | 0.04# | 0.10# |
| Mastectomy+ RT | 86 (21.5) | ||
| BCS + RT | 92 (19.4) | ||
| Chemotherapy | |||
| Anthracyclines | 165 (38.8) | 0.02* | 0.28* |
| Anthracyclines+Taxanes | 260 (61.2) |
Abbreviations: TNBC, triple-negative breast cancer; sTILs, stromal tumor-infiltrating lymphocytes; iTILs, intratumoral tumor-infiltrating lymphocytes; RT, radiotherapy; BCS, breast-conserving surgery.
*
Mann-Whitney test;
#
Kruskal-Wallis test.