Table 1. Baseline clinical characteristics of sTILs and iTILs in different TNBC groups.
Characteristics | N (%) | P-value of sTILs | P-value of iTILs |
---|---|---|---|
Age (years) | |||
≤ 50 | 196 (46.1) | 0.002* | 0.17* |
> 50 | 229 (53.9) | ||
Tumor size (cm) | |||
pT1 (0.1–2.0) | 180 (42.4) | 0.73# | 0.19# |
pT2 (2.1–5.0) | 227 (53.4) | ||
pT3 (>5.0) | 12 (2.8) | ||
Unknown | 6 (1.4) | ||
Nodal status | |||
pN0 (0) | 263 (61.9) | 0.08# | 0.95# |
pN1 (1–3) | 75 (17.6 ) | ||
pN2/N3 (4+) | 63 (14.8) | ||
Unknown | 24 (5.7) | ||
Histological grade | |||
2 | 136 (32) | < 0.001* | 0.005* |
3 | 289 (68) | ||
Histological type | |||
Invasive carcinoma of | 413 (97.2) | 0.33* | 0.25* |
no special type | |||
Special subtype | 12 (2.8) | ||
Local treatment | |||
Mastectomy | 247 (59.1) | 0.04# | 0.10# |
Mastectomy+ RT | 86 (21.5) | ||
BCS + RT | 92 (19.4) | ||
Chemotherapy | |||
Anthracyclines | 165 (38.8) | 0.02* | 0.28* |
Anthracyclines+Taxanes | 260 (61.2) |
Abbreviations: TNBC, triple-negative breast cancer; sTILs, stromal tumor-infiltrating lymphocytes; iTILs, intratumoral tumor-infiltrating lymphocytes; RT, radiotherapy; BCS, breast-conserving surgery.
Mann-Whitney test;
Kruskal-Wallis test.