Table 3. Univariate analysis for associations of TILs with DFS, DDFS and OS in TNBCs.
Variables | DFS | DDFS | OS | ||||||
---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P-value | HR | 95% CI | P-value | HR | 95% CI | P-value | |
sTILs(per 10% increase) | 0.97 | 0.95–0.99 | 0.001* | 0.96 | 0.94–0.98 | 0.001* | 0.96 | 0.94–0.99 | 0.003* |
iTILs(per 10% increase) | 0.98 | 0.91–1.05 | 0.53 | 0.98 | 0.91–1.06 | 0.57 | 1.02 | 0.95–1.10 | 0.61 |
LPBC v No LPBC | 0.25 | 0.04–1.83 | 0.17 | 0.05 | 0.01–6.03 | 0.22 | 0.05 | 0.03–13.6 | 0.29 |
sTILs ≤ 20% v sTILs > 20% | 0.24 | 0.10–0.60 | 0.002* | 0.16 | 0.05–0.51 | 0.002* | 0.23 | 0.07–0.73 | 0.01* |
Abbreviations: TNBCs: triple-negative breast cancers; sTILs, stromal tumor-infiltrating lymphocytes; iTILs, intratumoral tumor-infiltrating lymphocytes; LPBC, lymphocyte-predominant breast cancer; DFS, disease-free survival; DDFS, distant disease-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval.
The P value is significant.