Table 7. Multivariable cox-proportional hazard regression analysis in Chinese population (N = 1105).

M0 patients (N = 981)			M1 patients (N = 124)
	Multivariable HR*	P value		Multivariable HR†	P value
Treatment		< 0.001	Treatment		0.001
D1/D1+ without chemotherapy	1		D1/D1+ without chemotherapy	1
D1/D1+ with chemotherapy	0.63 [0.49–0.81]	< 0.001	D1/D1+ with chemotherapy	0.45 [0.25–0.79]	0.006
D2/D2+ without chemotherapy	0.86 [0.67–1.11]	0.244	D2/D2+ without chemotherapy	1.53 [0.88–2.63]	0.129
D2/D2+ with chemotherapy	0.44 [0.32–0.59]	< 0.001	D2/D2+ with chemotherapy	0.91 [0.53–1.57]	0.732
Radicality of surgery		0.001	Tumor size (cm)		0.005
R0	1		≤ 2	1
R1/R2	1.97 [1.30–2.99]		~5.0	3.43 [0.46–25.78]	0.232
Depth of infiltration (pT)		< 0.001	~8.0	5.81 [0.78–43.40]	0.087
pT1	1		> 8.0	7.73 [1.02–58.64]	0.048
pT2	2.28 [1.32–3.95]	0.003
pT3	3.31 [1.84–5.94]	< 0.001
pT4a	3.80 [2.34–6.18]	< 0.001
pT4b	4.18 [2.39–7.32]	< 0.001
Nodal status (pN)		< 0.001
pN0	1
pN1	1.82 [1.28–2.59]	0.001
pN2	1.80 [1.26–2.57]	0.001
pN3a	3.92 [2.83–5.43]	< 0.001
pN3b	5.25 [3.64–7.57]	< 0.001

Abbreviations: HR, hazard ratio.

^*forward selection (likelihood ratio) with treatment type, gender, age, surgical methods, tumor location, differentiation, tumor size, T stage, N stage, resection type, radicality of surgery.

^†forward selection (likelihood ratio) with treatment type, gender, age, surgical methods, tumor location, differentiation, tumor size, T stage, N stage, M stage, resection type, radicality of surgery.