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Effect of antisense-PNAs on MDM2 and p53 levels in JAR cells. Cells were transfected with PNA as complexes with complementary DNA and LFA for 24 h. Identical amounts of protein were analyzed by western blot using monoclonal anti MDM antibody and anti p53 antibody. (A) T1-12, T1-12-NLS, T5-12 and T5-12-NLS were used at 1 μM. (B) T5-12 was tested at 0.5, 1 and 2 μM. Mismatch PNA (T5-12-mm), holding 2 bp mismatches, was used at 2 μM.
