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. 2016 Dec 20;12:87–110. doi: 10.2147/IJN.S117495

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© 2017 Song et al. This work is published and licensed by Dove Medical Press Limited

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Schematic representation of H₂O₂-induced release of guest molecules clioquinol (CQ) from the pores of MSN capped with IgG.

Notes: CQ can chelate Cu²⁺ to disassemble Aβ plaques and inhibit H₂O₂ production. Reprinted with permission from John Wiley and Sons. Geng J, Li M, Wu L, Chen C, Qu X. Mesoporous silica nanoparticle-based H₂O₂ responsive controlled-release system used for Alzheimer’s disease treatment. Adv Healthc Mater.¹¹⁹ Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Abbreviations: MSN, mesoporous silica nanoparticle; IgG, immunoglobulin G; Aβ, amyloid-beta.