Figure 12.

Schematic illustration of the synthesis of hybrid silica nanoparticles coated with thermoresponsive PNIPAM brushes via RAFT polymerization and click chemistry.

Notes: Reprinted with permission from Chen J, Liu M, Chen C, Gong H, Gao C. Synthesis and characterization of silica nanoparticles with well-defined thermoresponsive PNIPAM via a combination of RAFT and click chemistry. ACS Appl Mater Interfaces. 2011;3(8):3215–3223. Copyright 2011 American Chemical Society.¹²⁸ The expression of (i) and (ii) indicates the addition order of the reaction materials.

Abbreviations: PNIPAM, poly N-isopropyl acrylamide; RAFT, reversible addition-fragmentation chain transfer; AIBN, azobisisobutyronitrile.