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. 2016 Dec 20;12:87–110. doi: 10.2147/IJN.S117495

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© 2017 Song et al. This work is published and licensed by Dove Medical Press Limited

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(A) Functionalization procedure of the MSN. (B) Drug-loaded MSN under physiological condition. (C) RGDS-targeted to the tumor cell. (D) Endocytosis into specific tumor cell. (E) Cathepsin B enzyme-triggered drug release in cytoplasm. (F) Apoptosis of the tumor cell. Reprinted with permission from Cheng YJ, Luo GF, Zhu JY, et al. Enzyme-induced and tumor-targeted drug delivery system based on multifunctional mesoporous silica nanoparticles. ACS Appl Mater Interfaces. 2015;7(17):9078–9087. Copyright 2015 American Chemical Society.¹⁰⁹

Abbreviations: MSN, mesoporous silica nanoparticle; DOX, doxorubicin hydrochloride; α-CD, α-cyclodextrin; RGDS, Arg-Gly-Asp-Ser; GFLG, Gly-Phe-Leu-Gly.