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. 2016 Dec 20;12:87–110. doi: 10.2147/IJN.S117495

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© 2017 Song et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Schematic representation of the glucose-responsive MSN-based delivery system for controlled release of bioactive G-Ins and cyclic AMP.

Note: Reprinted with permission from Cheng YJ, Zhao Y, Trewyn BG, Slowing II, Lin VS. Mesoporous silica nanoparticle-based double drug delivery system for glucose-responsive controlled release of insulin and cyclic AMP. J Am Chem Soc. 2009;131(24):8398–8400. Copyright 2009 American Chemical Society.¹¹³

Abbreviations: MSN, mesoporous silica nanoparticle; G-Ins, gluconic acid–modified insulin; BA-MSN, boronic acid-functionalized MSN.