. 2016 Dec 20;10:15–29. doi: 10.2147/JPR.S106578

Table S1.

Total rescue opioid consumption and total number of rescue opioid doses among patients receiving intravenous HPβCD-diclofenac, ketorolac, or placebo for acute postsurgical pain

	Cumulative rescue opioid consumption, mg (SD)
	HPβCD-diclofenac 18.75 mg (n=132)	HPβCD-diclofenac 37.5 mg (n=150)	HPβCD-diclofenac 50 mg (n=36)	HPβCD-diclofenac all doses (n=318)	Ketorolac (n=142)	Placebo (n=148)
Time interval (hours)
0–24	7.36 (7.47)^*	6.11 (7.04)^*	6.64 (6.91)^*	6.69 (7.21)^*	7.41 (8.03)^*	13.13 (9.55)
0–48	8.89 (9.79)^*	7.25 (9.22)^*^,^{^}	8.04 (8.65)^*	8.02 (9.40)^*	9.74 (11.80)^*	16.82 (13.42)
0–72	9.22 (10.20)^*	7.41 (9.48)^*^,^{^}	8.94 (10.00)^*	8.34 (9.85)^*^,^{^}	10.57 (14.64)^*	17.67 (14.94)
0–96	9.31 (10.35)^*	7.41 (9.48)^*^,^{^}	8.94 (10.00)^*	8.37 (9.92)^*^,^{^}	10.59 (14.66)^*	17.69 (14.94)
0–120	9.31 (10.35)^*	7.41 (9.48)^*^,^{^}	8.94 (10.00)^*	8.37 (9.92)^*^,^{^}	10.61 (14.68)^*	17.69 (14.94)

	Cumulative number of rescue opioid doses (SD)
	HPβCD-diclofenac 18.75 mg (n=132)	HPβCD-diclofenac 37.5 mg (n=150)	HPβCD-diclofenac 50 mg (n=36)	HPβCD-diclofenac all doses (n=318)	Ketorolac (n=142)	Placebo (n=148)

Time interval (hours)
0–24	2.59 (2.42)^*	1.95 (2.38)^*	2.56 (2.73)^*	2.28 (2.45)^*	2.53 (2.78)^*	4.34 (3.20)
0–48	3.11 (3.13)^*	2.29 (2.98)^*^,^{^}	3.00 (3.14)^*	2.71 (3.08)^*	3.22 (3.55)^*	5.42 (4.28)
0–72	3.22 (3.27)^*	2.34 (3.04)^*^,^{^}	3.33 (3.61)^*	2.82 (3.23)^*^,^{^}	3.42 (3.95)^*	5.70 (4.81)
0–96	3.26 (3.34)^*	2.34 (3.04)^*^,^{^}	3.33 (3.61)^*	2.83 (3.26)^*^,^{^}	3.42 (3.97)^*	5.70 (4.82)
0–120	3.26 (3.34)^*	2.34 (3.04)^*^,^{^}	3.33 (3.61)^*	2.83 (3.26)^*^,^{^}	3.43 (3.98)^*	5.70 (4.82)

Notes:

P<0.0001 versus placebo,

^{^}

P<0.05 versus ketorolac from least-square mean difference based on ANCOVA model with treatment, study, and center as factors and baseline pain as a covariate.

Abbreviations: ANCOVA, analysis of covariance; HPβCD, hydroxypropyl-β-cyclodextrin; SD, standard deviation.