Table S3.

Total number of rescue opioid doses, by baseline pain severity, among patients receiving intravenous HPβCD-diclofenac, ketorolac, or placebo for acute postsurgical pain

	Cumulative number of rescue opioid doses (SD)
	Moderate baseline pain (≥50 and <70 mm on 0–100 mm VAS)
	HPβCD-diclofenac 18.75 mg (n=84)	HPβCD-diclofenac 37.5 mg (n=76)	HPβCD-diclofenac 50 mg (n=23)	HPβCD-diclofenac all doses (n=183)	Ketorolac (n=82)	Placebo (n=91)
Time interval (hours)
0–24	2.37 (2.45)#	1.67 (2.47)#	2.26 (2.24)#	2.07 (2.44)#	2.17 (2.42)#	4.25 (3.22)
0–48	2.79 (2.92)#	1.99 (3.15)#	2.83 (3.00)#	2.46 (3.04)#	2.93 (3.49)*	5.15 (4.34)
0–72	2.89 (3.06)#	2.01 (3.18)#	3.30 (3.72)*	2.58 (3.22)#	3.15 (3.97)*	5.40 (4.96)
0–96	2.95 (3.19)#	2.01 (3.18)#	3.30 (3.72)*	2.61 (3.28)#	3.16 (4.00)*	5.41 (4.96)
0–120	2.95 (3.19)#	2.01 (3.18)#	3.30 (3.72)*	2.61 (3.28)#	3.17 (4.02)*	5.41 (4.96)
	Severe baseline pain (≥70 mm on 0–100 mm VAS)
	HPβCD-diclofenac 18.75 mg (n=47)	HPβCD-diclofenac 37.5 mg (n=73)	HPβCD-diclofenac 50 mg (n=13)	HPβCD-diclofenac all doses (n=133)	Ketorolac (n=58)	Placebo (n=57)
Time interval (hours)
0–24	2.91 (2.34)*	2.21 (2.27)#	3.08 (3.48)*	2.54 (2.44)#	3.12 (3.17)*	4.47 (3.21)
0–48	3.60 (3.40)*	2.59 (2.79)#	3.31 (3.50)*	3.02 (3.10)#	3.74 (3.62)*	5.84 (4.20)
0–72	3.70 (3.55)*	2.66 (2.89)#	3.38 (3.55)*	3.10 (3.21)#	3.91 (3.93)*	6.18 (4.58)
0–96	3.70 (3.55)*	2.66 (2.89)#	3.38 (3.55)*	3.10 (3.21)#	3.91 (3.93)*	6.18 (4.58)
0–120	3.70 (3.55)*	2.66 (2.89)#	3.38 (3.55)*	3.10 (3.21)#	3.91 (3.93)*	6.18 (4.58)

Notes:

^*P<0.005 versus placebo,

^#P<0.0001 versus placebo versus ketorolac from least-square mean difference based on ANCOVA model with treatment, study, and center as factors and baseline pain as a covariate.

Abbreviations: ANCOVA, analysis of covariance; HPβCD, hydroxypropyl-β-cyclodextrin; SD, standard deviation; VAS, visual analog scale.