Table 1.
Device categorization used to form study cohorts
| Categorization of devicesa
| |
|---|---|
| Main analysis | Sensitivity analysis |
| Aerosols: manual-activated MDI, manual-activated MDI with spacer, breath-actuated MDI and soft mist inhaler (pMDIs, CFC-free inhalers, breath-actuated inhalers, Clenil modulite, pMDIs + pacer, Autohaler, Easibreathe, Respimat) | Aerosols: same as in main analysis |
| DPIs: single-dose capsule DPI (Breezhaler, Aerolizer, Handihaler), multi-dose DPI with medium resistance (Accuhaler [Diskus], Novolizer, Genuair, Elipta) and multi-dose DPI with medium–high or high resistance (Turbohaler, Clickhaler, Pulvinal, Twisthaler, Easyhaler, Duoresp) |
Single-dose capsule DPI (Breezhaler, Aerolizer, Handihaler) Multi-dose DPI with medium resistance: (Accuhaler [Diskus], Novolizer, Genuair, Ellipta) Multi-dose DPI with medium–high or high resistance (Turbohaler, Clickhaler, Pulvinal, Twisthaler, Easyhaler, Duoresp) |
Note:
a
Devices from within categories (identified with headings in bold) are considered “similar” and devices from more than one category are considered “mixed”.
Abbreviations: DPI, dry-powder inhaler; MDI, metered dose inhaler; pMDI, pressurized metered dose inhaler.