Table 2.
Main KEGG pathways significantly relating to major hubs
| KEGG pathways | Counts | P-value |
|---|---|---|
| hsa04664:Fc epsilon RI signaling pathway | 34 | 2.36×10−16 |
| hsa04662:B cell receptor signaling pathway | 31 | 3.96×10−14 |
| hsa04660:T cell receptor signaling pathway | 34 | 1.41×10−11 |
| hsa04620:Toll-like receptor signaling pathway | 29 | 6.16×10−9 |
| hsa04080:Neuroactive ligand–receptor interaction | 46 | 8.02×10−7 |
| hsa04621:NOD-like receptor signaling pathway | 19 | 1.62×10−6 |
| hsa04270:Vascular smooth muscle contraction | 26 | 3.58×10−6 |
| hsa04630:Jak-STAT signaling pathway | 31 | 8.62×10−6 |
| hsa04650:Natural killer cell-mediated cytotoxicity | 27 | 2.89×10−5 |
| hsa04060:Cytokine–cytokine receptor interaction | 36 | 0.003305 |
| hsa05310:Asthma | 8 | 0.008380 |
| hsa05130:Pathogenic Escherichia coli infection | 10 | 0.045010 |
Abbreviation: KEGG, Kyoto Encyclopedia of Genes and Genomes.