Table 4.
Mixture number | Formulation composition
|
Response measured
|
|||
---|---|---|---|---|---|
X1 (w/w) | X2 (mg) | Y1 (%) | Y2 (%) | Y3 (hours) | |
1 | 1:2 | 7.5 | 23.5 | 59.1 | 14 |
2 | 2:1 | 7.5 | 91.4 | 98.4 | 12.3 |
3 | 1:2 | 30 | 0.5 | 2.7 | 18.5 |
4 | 2:1 | 30 | 26 | 45 | 15 |
5 | 1:2 | 7.5 | 25.4 | 60.7 | 13.2 |
6 | 2:1 | 7.5 | 96.2 | 100 | 11.8 |
7 | 1:2 | 30 | 0.5 | 2.9 | 18.8 |
8 | 2:1 | 30 | 27.6 | 44.5 | 15.5 |
9 | 1:2 | 7.5 | 23.4 | 60.1 | 13.2 |
10 | 2:1 | 7.5 | 93.6 | 97.6 | 12.5 |
11 | 1:2 | 30 | 0.7 | 3.4 | 18 |
12 | 2:1 | 30 | 24.7 | 43.4 | 15.5 |
13 | 1:1 | 18.75 | 28.9 | 45.1 | 14 |
14 | 1:1 | 18.75 | 26.7 | 44.8 | 14.5 |
15 | 1:1 | 18.75 | 27.1 | 44.6 | 14.6 |
Notes: X1, polymer composition; X2, amount of subcoating; Y1, dissolution efficiency in simulated colonic fluid; Y2, dissolution efficiency in chitosanase-supplemented simulated colonic fluid; Y3, controlled-release duration in the colon.
Abbreviation: 2-LFD, two-level factorial design.