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. 2016 Dec 21;11:45–57. doi: 10.2147/DDDT.S123412

Table 5.

Estimated effects and coefficients

Terms Regression coefficient Standard-error coefficient t-Value P-value
DEcolon (SCF) (%; Y1)a
 Constant 36.13 0.4191 86.19 0.000
 X1 23.79 0.4191 56.76 0.000
 X2 −22.79 0.4191 −54.38 0.000
 X1·X2 −11.02 0.4191 −26.31 0.000
DEcolon (CTNase-SCF) (%; Y2)b
 Constant 51.48 0.224 229.86 0.000
 X1 20 0.224 89.29 0.000
 X2 −27.83 0.224 −124.27 0.000
 X1·X2 0.65 0.224 2.9 0.016
CRDcolon (h; Y3)c
 Constant 14.86 0.1075 138.22 0.000
 X1 −1.09 0.1075 −10.16 0.000
 X2 2.03 0.1075 18.84 0.000
 X1·X2 −0.46 0.1075 −4.26 0.002

Notes: X1, polymer composition; X2, amount of subcoating.

a

R2=99.86%, predicted R2=97.92%, adjusted R2=97.39%;

b

R2=99.96%, predicted R2=98.79%, adjusted R2=99.94%;

c

R2=97.96%, predicted R2=94.46%, adjusted R2=97.14%.

Abbreviations: CRD, controlled-release duration; CTNase, chitosanase; DE, dissolution efficiency; DEcolon, DE in the colon; SCF, simulated colonic fluid.