Table 5.
Estimated effects and coefficients
| Terms | Regression coefficient | Standard-error coefficient | t-Value | P-value |
|---|---|---|---|---|
| DEcolon (SCF) (%; Y1)a | ||||
| Constant | 36.13 | 0.4191 | 86.19 | 0.000 |
| X1 | 23.79 | 0.4191 | 56.76 | 0.000 |
| X2 | −22.79 | 0.4191 | −54.38 | 0.000 |
| X1·X2 | −11.02 | 0.4191 | −26.31 | 0.000 |
| DEcolon (CTNase-SCF) (%; Y2)b | ||||
| Constant | 51.48 | 0.224 | 229.86 | 0.000 |
| X1 | 20 | 0.224 | 89.29 | 0.000 |
| X2 | −27.83 | 0.224 | −124.27 | 0.000 |
| X1·X2 | 0.65 | 0.224 | 2.9 | 0.016 |
| CRDcolon (h; Y3)c | ||||
| Constant | 14.86 | 0.1075 | 138.22 | 0.000 |
| X1 | −1.09 | 0.1075 | −10.16 | 0.000 |
| X2 | 2.03 | 0.1075 | 18.84 | 0.000 |
| X1·X2 | −0.46 | 0.1075 | −4.26 | 0.002 |
Notes: X1, polymer composition; X2, amount of subcoating.
a
R2=99.86%, predicted R2=97.92%, adjusted R2=97.39%;
b
R2=99.96%, predicted R2=98.79%, adjusted R2=99.94%;
c
R2=97.96%, predicted R2=94.46%, adjusted R2=97.14%.
Abbreviations: CRD, controlled-release duration; CTNase, chitosanase; DE, dissolution efficiency; DEcolon, DE in the colon; SCF, simulated colonic fluid.