Table 2. Associations between current adiposity measures and log-transformed leukocyte telomere length (LTL).
N | Weighted % | Mean LTL (SE) | Log LTL difference1 | Log LTL difference2 | Log LTL difference2,3 | ||||
---|---|---|---|---|---|---|---|---|---|
β | 95% CI | β | 95% CI | β | 95% CI | ||||
BMI, kg/m2 | |||||||||
Continuous | −0.002 | −0.004, −0.0007 | −0.002 | −0.003, −0.0006 | −0.002 | −0.003, −0.0007 | |||
Clinical cut-off | |||||||||
<18.5 | 104 | 17.54 | 1.07 (0.03) | −0.04 | −0.08, 0.005 | −0.03 | −0.07, 0.01 | −0.03 | −0.07, 0.01 |
18.5-25 | 2137 | 33.07 | 1.09 (0.02) | Reference | Reference | Reference | |||
25-30 | 2556 | 35.09 | 1.04 (0.02) | −0.02 | −0.04, 0.002 | −0.02 | −0.04, 0.002 | −0.02 | −0.04, 0.004 |
≥30 | 2211 | 30.08 | 1.03 (0.02) | −0.04 | −0.06, −0.01 | −0.03 | −0.05, −0.009 | −0.03 | −0.05, −0.01 |
Waist circumference4 | |||||||||
Continuous | −0.001 | −0.002, −0.0004 | −0.0008 | −0.001, −0.0003 | −0.0009 | −0.001, −0.0003 | |||
Clinical cut-off | |||||||||
Normal | 3437 | 52.11 | 1.09 (0.02) | Reference | Reference | Reference | |||
High | 3571 | 47.89 | 1.02 (0.02) | −0.03 | −0.05, −0.009 | −0.02 | −0.04, −0.006 | −0.02 | −0.04, −0.006 |
Percent body fat5 | |||||||||
Continuous | −0.002 | −0.003, −0.0004 | −0.002 | −0.003, −0.0003 | −0.001 | −0.003, −0.00005 | |||
Clinical cut-off | |||||||||
Normal | 1122 | 40.46 | 1.16 (0.02) | Reference | Reference | Reference | |||
High | 1746 | 59.54 | 1.11 (0.02) | −0.03 | −0.05, −0.01 | −0.03 | −0.05, −0.009 | −0.02 | −0.04, −0.005 |
Adjusted for age at LTL measurement (continuous), sex, and race/ethnicity
Adjusted for age at LTL measurement (continuous), sex, race/ethnicity, education, smoking status, alcohol intake, vigorous physical activity
Additional adjustment for diabetes, hypertension, hypertriglyceridemia, low HDL, and self-reported cancer diagnosis
Normal: ≤102 cm (men) and ≤88 cm (women); high: >102 cm (men) and >88 cm (women)
Measured in 2,868 individuals aged 20-49 years. Normal: ≤25% (men) and ≤35% (women); high: >25% (men) and >35%