Table 4. Associations between overweight trajectories and telomere length, stratified by age at examination.
| Age at examination | N (%) | Mean BMI (SE) | Mean LTL(SE) | Log LTL difference1 | ||
| At age 25 | At examination | β | 95% CI | |||
| Age 30-39 | ||||||
| Non-overweight/non-overweight | 393 (36.07) | 20.81 (0.11) | 22.14 (0.10) | 1.13 (0.02) | Ref | |
| Non-overweight /overweight | 368 (29.97) | 22.44 (0.12) | 28.97 (0.21) | 1.13 (0.02) | -0.009 | -0.04, 0.02 |
| Overweight/non-overweight | 26 (2.16) | 27.09 (0.31) | 23.52 (0.25) | 0.99 (0.03) | -0.12 | -0.20, -0.05 |
| Overweight/overweight | 395 (31.80) | 29.53 (0.23) | 33.69 (0.39) | 0.99 (0.04) | -0.13 | -0.19, -0.02 |
| Age 40-49 | ||||||
| Non-overweight/non-overweight | 320 (28.46) | 20.59 (0.12) | 22.10 (0.12) | 1.12 (0.02) | Ref | |
| Non-overweight /overweight | 571 (41.46) | 21.88 (0.10) | 29.45 (0.24) | 1.05 (0.02) | -0.06 | -0.11, -0.02 |
| Overweight/non-overweight | 37 (3.58) | 27.09 (0.31) | 23.29 (0.31) | 1.13 (0.05) | 0.006 | -0.08, 0.09 |
| Overweight/overweight | 360 (26.50) | 28.83 (0.36) | 34.30 (0.58) | 1.05 (0.03) | -0.07 | -0.13, -0.009 |
| Age 50-59 | ||||||
| Non-overweight/non-overweight | 239 (26.75) | 20.28 (0.13) | 22.46 (0.13) | 0.99 (0.02) | Ref | |
| Non-overweight /overweight | 492 (49.13) | 21.97 (0.13) | 29.45 (0.24) | 0.98 (0.02) | -0.005 | -0.05, 0.04 |
| Overweight/non-overweight | 19 (1.49) | 27.12 (0.61) | 23.44 (0.42) | 1.14 (0.07) | 0.12 | 0.01, 0.24 |
| Overweight/overweight | 225 (22.63) | 28.52 (0.32) | 33.79 (0.69) | 1.01 (0.02) | 0.03 | -0.03, 0.08 |
| Age 60-69 | ||||||
| Non-overweight/non-overweight | 253 (23.86) | 20.52 (0.14) | 22.54 (0.14) | 0.96 (0.02) | Ref | |
| Non-overweight /overweight | 649 (54.02) | 21.44 (0.09) | 30.33 (0.25) | 0.96 (0.02) | -0.01 | -0.06, 0.03 |
| Overweight/non-overweight | 16 (1.01) | 26.25 (0.37) | 23.35 (0.50) | 0.89 (0.07) | -0.05 | -0.22, 0.10 |
| Overweight/overweight | 251 (21.11) | 27.66 (0.23) | 33.16 (0.38) | 0.96 (0.02) | 0.001 | -0.05, 0.06 |
| Age 70-85 | ||||||
| Non-overweight/non-overweight | 393 (32.49) | 20.64 (0.12) | 22.23 (0.15) | 0.87 (0.02) | Ref | |
| Non-overweight /overweight | 676 (53.88) | 21.24 (0.08) | 29.64 (0.18) | 0.86 (0.01) | -0.009 | -0.04, 0.03 |
| Overweight/non-overweight | 39 (2.15) | 28.05 (0.60) | 22.93 (0.41) | 0.87 (0.05) | 0.02 | -0.10, 0.13 |
| Overweight/overweight | 179 (11.48) | 27.57 (0.20) | 30.80 (0.37) | 0.88 (0.03) | 0.03 | -0.04, 0.10 |
Note: Trajectories reflect overweight status at age 25, followed by that at current age, e.g. non-overweight/overweight refers to non-overweight at age 25 and overweight at current age.
1
All models were adjusted for sex, race/ethnicity, education, smoking status, alcohol intake, and vigorous physical activity.