Figure 1.

(A) Image of one long-term ad libitum (AL)- and of one caloric-restricted (CR)-fed ApoE−/− mouse. These mice were fed either AL or CR (60% of ad libitum). These images exemplarily show that in general CR-fed mice were smaller in body size than AL-fed mice. (B) Body weight (g) of AL- and CR-fed mice over a period of 68 weeks. In general, parameter of ketogenesis and lipolysis are increased in CR-fed mice when compared with the age-matched AL-fed mice indicated by a marked rise of (C) plasma β-hydroxybutyrate and of neuronal (D) pparγ and (E) abca1 mRNA expressions. Values are given as mean±SEM; ANOVA, post-hoc pairwise comparison tests: * p < 0.05 vs. AL.