Table 4. Validated aging targets of five miRNAs from the pilot study.
| miRNA * | Validated aging target mRNAs ‡ |
|---|---|
| miR-211 | CREB5 |
| DDIT4 | |
| IGF2R | |
| miR-340 | LMNA |
| ARHGAP | |
| MPHOSPH | |
| IFG2 | |
| YWHAZ | |
| EEF1A1 | |
| JUN | |
| PTEN | |
| CDKN2A | |
| HGF | |
| miR-374a | EP300 |
| ATM | |
| HMGB2 | |
| CISH | |
| PARP1 | |
| BCL2 | |
| TP73 | |
| CDKN1A | |
| miR-376 | IGF1R |
| miR-1225 | JUND |
| PARP1 | |
| PRDX1 |
*
miR-5095 was not listed here because it did not have any validated aging targets.
‡
miRTarBase + miRWalk, overlap with GenAge. Note that PARP1 (Poly(ADP-ribose) Polymerase 1) mRNA is a validated target of both miR-374a and miR-1225.