Figure 3. ClueGo network analysis of differentially expressed genes reveal robust activation of p53-related pathways.

Differentially expressed genes 2 days after DEN in 1-month old (A) and 6-month-old mice (B) and common and exclusively differentially expressed genes between the two ages (C), were annotated in the context of the GO database, and the relationships among these annotated terms were calculated and grouped by ClueGO to create an annotation module network. Functionally grouped networks with pathways and genes are shown. The node size represents the term enrichment significance.