. Author manuscript; available in PMC: 2017 Oct 1.

Published in final edited form as: Metabolism. 2016 Jun 24;65(10):1489–1497. doi: 10.1016/j.metabol.2016.06.002

Table 2.

Association of NT-proBNP with incident diabetes

	Quartile 1	Quartile 2	Quartile 3	Quartile 4	Overall
Events/Individuals at risk (n)	105/590	95/590	85/590	63/589	348/2359
Incidence (per 1000 py)^*	14.0	13.3	12.2	10.5	12.6
	HR vs. referent (95% CI), p Value				HR per doubling (95% CI), p Value
Model 1^†	1.00 (Ref.)	0.99 (0.75 – 1.31) p=0.93	0.92 (0.68 – 1.24) p=0.59	0.82 (0.59 – 1.13) p=0.24	0.93 (0.85 – 1.01) p=0.10
Model 2^‡	1.00 (Ref.)	0.95 (0.71 – 1.26) p=0.71	0.93 (0.69 – 1.25) p=0.62	0.76 (0.54 – 1.07) p=0.11	0.91 (0.84 – 0.99) p=0.039

p=0.060 for trend across quartiles.

^†

Adjusted by age, sex, race.

^‡

Adjusted by age, sex, race, body mass index, systolic blood pressure, antihypertensive medication, smoking status, alcohol consumption, and low density lipoprotein cholesterol.

CI=Confidence interval. HR=Hazard ratio. PY= Person-years.