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Model of the proposed structure of the cystic fibrosis transmembrane conductance regulator (CFTR) channel. The CFTR is a member of the ABC transporter family that functions a Cl- channel. It is located in the apical membrane of epithelia. The CFTR is composed of five domains which include two membrane-spanning domains (MSD-1 and -2), two nucleotide-binding domains (NBD-1 and -2), and a regulatory (R) domain.
