Figure 2. Organ-chips as quality assurance systems for regenerative medicine.

Organ-chips are engineered in-vitro platforms that enable multiparametric assessment of the phenotype of cells exposed to healthy and diseased microenvironments. We recently developed a cardiac cell therapy on-a-chip platform using primary and stem cell-derived cardiomyocytes, as proxies for speared and newly formed myocytes. Our characterization of the cell structural and functional phenotype was consistent with previously published in-vivo observations suggesting organ-chips may enable comprehensive characterization of cell products for regenerative medicine. Figure panels were reproduced with permission [4, 5].