Table 5.
Potassium channel gene S-scores in the nucleus accumbens that significantly correlated with the change in voluntary drinking after chronic intermittent ethanol exposure of BXD mice.
Gene | Probe set | Protein | r | R2 | P value | Functional Class | Subcellular Localization |
---|---|---|---|---|---|---|---|
Kcna4 | 1422255_at | Kv1.4 | 0.477 | 0.227 | 0.029 | A-type voltage-gated | Axon/Terminals |
Kcnh2 | 1449544_a_at | Kv11.1 | 0.527 | 0.277 | 0.014 | Inwardly rectifying voltage-gated | Unknown |
Kcnh7 | 1427634_at | Kv11.3 | 0.467 | 0.218 | 0.033 | Voltage-gated | Unknown |
Kcnj1 | 1418613_at | Kir1.1 | −0.538 | 0.289 | 0.012 | Inwardly rectifying | Unknown |
Kcnj8 | 1418142_at | Kir6.1 | −0.451 | 0.203 | 0.04 | ATP-sensitive | Dendrites |
Kcnj11 | 1455417_at | Kir6.2 | 0.484 | 0.235 | 0.026 | ATP-sensitive | Dendrites |
Kcnj16 | 1435094_at | Kir5.1 | −0.455 | 0.207 | 0.038 | Inwardly rectifying | Unknown |
Kcnq1 | 1459443_at | Kv7.1 | −0.507 | 0.257 | 0.019 | M-current delayed rectifier | Axon/Terminals |
1449464_at | −0.451 | 0.204 | 0.04 | ||||
Kcnq5 | 1457587_at | Kv7.5 | 0.625 | 0.391 | 0.002 | M-current delayed rectifier | Axon/Terminals |
Kcns1 | 1421518_at | Kv9.1 | −0.545 | 0.297 | 0.011 | Modifier/silencer of Kv2 currents | Unknown |
Kcns2 | 1457325_at | Kv9.2 | 0.472 | 0.223 | 0.031 | Modifier/silencer of Kv2 currents | Unknown |
Kcnv2 | 1440537_at | Kv8.2 | 0.538 | 0.29 | 0.012 | Modifier/silencer of Kv2 currents | Unknown |