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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jun 27;9(2):10.1002/wnan.1418. doi: 10.1002/wnan.1418

Figure 6.

Figure 6

(a) Schematics of RSPN structure and ROS sensoring mechanism. (b) PA spectra of RSPN in the absence and presence of H2O2 and ONOO−. ([RSPN]= 5 μg mL−1, [ROS]= 5 μM). (c) Ratio of PA amplitude at 700 nm to that at 820 nm (PA700/PA820) of RSPN treated with various ROS ([ROS]= 5 μM). (d) Representative PA image of RAW264.7 cell pellets embedded in alga phantom with or without stimulation of LPS/INF-γ, and with NAC protection. (e) Quantification of PA700/PA820 for cell pellets with or without stimulation of LPS/INF-γ, and with NAC protection (n=4, P<0.05). (f) Real-time in vivo PA imaging of mouse acute edema induced by Zymosan after intramuscular injection of RSPN. (g) PA700/PA820 value as a function of time post-injection of RSPN. (Statistically significant difference started from 10 min post-injection, P<0.05). Reproduced from Ref [41]. Copyright Nature Publishing Group.