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The full reference tissue model (a) and simplified reference tissue model (b) use a single compartment to describe the concentration of PET radioligand in the reference region (CR) so that the plasma concentration (CP) is not needed in analysis. FRTM partitions other tissue concentrations into free (CF) and specifically bound (CB) fractions, whereas SRTM assumes fast exchange between these compartments and thus approximates all tissues using a single compartment model.
