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Functional activity of the 5-HT1A receptor. Binding of serotonin (5-HT) to the 5-HT1A receptor, both pre-synaptic and post-synaptic subtypes, signals the opening of a hyperpolarizing potassium (K+) channel and inhibition of adenylyl cyclase (AC). These actions, mediated by G proteins (Gi/Go), serve to hyperpolarize the cell and reduce its firing rate. Gray circles associated with K+ channel represent K+ ions moving into extracellular space.
