Table 2.

Multivariable logistic regression model of persistence to therapy and switching among biologic agents

	Persistence			Switch
	OR	95% CI	p-Value	OR	95% CI	p-Value
Male	1.073	0.653–1.761	0.782	1.268	0.692–2.323	0.441
Age	1.000	0.985–1.016	0.970	0.990	0.971–1.010	0.335
CCI	0.934	0.824–1.060	0.291	1.110	0.951–1.296	0.185
Drug dose escalation	0.848	0.452–1.591	0.608	2.751	1.404–5.389	0.003
Drug dose reduction	0.855	0.469–1.558	0.609	1.631	0.780–3.409	0.194
Etanercept	ref.			ref.
Adalimumab	0.511	0.317–0.822	0.006	2.066	1.103–3.867	0.023
Infliximab	0.759	0.428–1.348	0.347	1.714	0.823–3.572	0.150

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; CCI, Charlson Comorbidity Index.