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. 2016 Dec 22;9:19–29. doi: 10.2147/CEOR.S117200

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© 2017 Lin et al. This work is published and licensed by Dove Medical Press Limited

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(A) Participant flow chart. (B) Schematic of study design.

Notes: *The initiation of the second drug in the combination therapy (eg, insulin plus GLP-1, or GLP-1 plus insulin) is defined as the index event, with the corresponding date as the index date. To ensure that patients received combination therapy after the index date, they were required to have ≥14 days of overlap for both therapies in the 90 days after the index date.

Abbreviations: T2D, type 2 diabetes; GLP-1, glucagon-like peptide-1.