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. 2016 Dec 16;5(12):e117. doi: 10.1038/cti.2016.72

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Copyright © 2016 The Author(s)

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Anti-FcRII antibody blocks ZIKV enhancement activity of anti-DENV serum. K562 cells were pre-incubated with increasing concentrations of mouse anti-FcRII (CD32) MAb prior to infection with ZIKV MR766 that had been pre-incubated with a highly enhancing dilution (1:50 000) of Singapore 1 serum. The results indicate that the ZIKV enhancement effect can be effectively blocked in a dose-responsive manner with an anti-FcRII MAb. This effect was statistically significant at all concentrations by analysis of variance with Dunnett's post hoc, P<0.05.