Figure 3.

Enhanced expression of CD38 and augmented efficacy of cytotoxicity of anti-CD38-CAR T cells against AML cell line cells by ATRA. AML cell line cells were incubated with or without effectors at an E:T ratio of 1:2 in the presence of ATRA (10 nM) for 3 days. T cells with anti-CD38-CAR killed an AML cell line (far right column), although T cells with an empty vector had no impact on cytotoxicity against the AML cell line, as shown in the fourth column.