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. 2016 Dec 9;48(12):e276. doi: 10.1038/emm.2016.113

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Copyright © 2016 KSBMB.

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ALS-motor neurons show distinct characteristics of ALS. (a) Immunostaining of differentiated WT-MNs and ALS-MNs. Islet-1 (green) is a motor neuron marker and Tuj-1 (red) is a pan neuronal marker. Scale bar, 20 μm. (b) Relative neurite length of ALS-MNs (0.68) was shorter than WT-MNs (1) at 1 week after differentiation (P<0.005). (n=20 (WT), 22 (ALS)) Error bar reflects s.d. (c) Relative neurite length of ALS-MNs (0.56) was shorter than WT-MNs (1) at 3 weeks after differentiation (P<0.001). (n=25 (WT), 14 (ALS)) Error bar reflects s.d. (d) White arrows in immunostained ALS-MNs show mutant SOD1 aggregates in motor neurons. Scale bar, 200 μm