FIG 2.

Organotellurium compounds chemosensitize S. cerevisiae AD strains overexpressing the C. albicans efflux pumps CaCdr1p, CaCdr2p, and CaMdr1p to fluconazole (FLC). Columns labeled “fluconazole (−)” show the growth of serial 5-fold dilutions of the indicated S. cerevisiae strains on YPD agar in the absence of FLC; columns labeled “fluconazole (+)” show the growth of the same serial dilutions of the indicated strains on YPD medium in the presence of subinhibitory concentrations of FLC (∼1/2 to ∼1/4 of their respective MICs). Cells grown on YPD with or without FLC only or on 0.5% DMSO were used as positive controls. Rows 1, 2, 3, 4, and 5 show the growth of the same cells in the presence of 100 μM compounds 1 to 5 (34, 35, 36, 38, and 40 μg/ml, respectively).