FIG 8.
Organotellurium compounds 1 to 5 chemosensitize C. albicans clinical FLC-resistant isolates. “Fluconazole (−)” columns show the growth of serial 5-fold dilutions of the indicated C. albicans isolates on Sabouraud agar in the absence of FLC; the fluconazole-positive columns show the growth of the same serial dilutions of the indicated isolates on Sabouraud medium in the presence of subinhibitory concentrations of FLC (i.e., ∼1/5 of the MICFLC for C. albicans isolates 95-142 and 12-99 and almost as much FLC as its MICFLC for C. albicans 96-25). Cells grown on Sabouraud agar with or without FLC only or 0.5% DMSO were used as positive controls, and cells grown on 10 μM FK506 (i.e., 8.0 μg/ml) were used as negative controls. Rows 1, 2, 3, 4, and 5 show the growth of the same cells in the presence of 100 μM concentrations of compounds 1 to 5 (i.e., 34, 35, 37, 38, and 40 μg/ml, respectively).