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Kinetic parameters of CTX-M-190 and CTX-M-55a
| Substrate | CTX-M-190 |
CTX-M-55 |
||||
|---|---|---|---|---|---|---|
| Km (μM) | kcat (s−1) | kcat/Km (μM−1 s−1) | Km (μM) | kcat (s−1) | kcat/Km (μM−1 s−1) | |
| Ampicillin | 46.9 | 101.7 | 2.2 | 114.9 | 422.6 | 3.7 |
| Nitrocefin | 26.6 | 21.9 | 0.82 | 25.5 | 9.2 | 0.36 |
| Piperacillin | 44.3 | 58.4 | 1.3 | 21.9 | 46.4 | 2.1 |
| Cefotaxime | 11.3 | 164.3 | 14.5 | 16.6 | 125.8 | 7.6 |
| Ceftazidime | 378.7 | 5.5 | 0.015 | 758.7 | 6.9 | 0.009 |
| Cefepime | 168.4 | 16.4 | 0.097 | 594.1 | 7.3 | 0.012 |
Data are the averages of the results obtained from three independent experiments.
