TABLE 1.

Noncompartmental PK results^a

	Value(s)
Parameter	Day 1 (n = 13)				Day 7 (n = 13)
	Mean	SD	Median	Range	Mean	SD	Median	Range
AUC0–24 (μg · h/ml)	0.971	0.51	1.03	0.205–1.94	5.05	1.07	5.00	3.47–6.48
AUC0–last (μg · h/ml)	0.918	0.557	1.03	0.184–1.94	156.0	83.7	130.0	67.8–353
Cmax (μg/ml)	0.102	0.039	0.098	0.0446–0.167	0.312	0.0823	0.31	0.168–0.457
Tmax (h)	1.46	0.43	1.50	1.00–2.00	1.65	0.75	1.50	0.50–3.00
t1/2 (h)	ND	ND	ND	ND	844	576	681	381–2580
RAUC	ND	ND	ND	ND	6.88	4.84	4.74	3.21–21.3
RCmax	ND	ND	ND	ND	3.38	1.30	2.84	2.30–6.17

^aND, not determined; RAUC, accumulation ratio for AUC, calculated as [AUC_0–24 (day 7)/AUC_0–24 (day 1)]; RC_max, accumulation ratio for C_max, calculated as [C_max (day 7)/C_max (day 1)].