TABLE 2.
Population PK resultsa
| Parameter | Value(s) |
|||
|---|---|---|---|---|
| PopPK parameter estimate | PopPK BS median (2.5th–97.5th percentile) | Bayesian estimate geometric mean | Bayesian estimate SD | |
| CL (liters/h) | 0.055 | 0.050 (0.0035–0.0735) | 0.056 | 0.024 |
| V1 (liters) | 13.5 | 13.5 (9.42–18.30) | 13.6 | 2.8 |
| Qrapid (liters/h) | 4.71 | 5.51 (4.00–7.94) | 4.71b | NA |
| V2 (liters) | 39.3 | 40.80 (33.60–48.20) | 39.7 | 7.4 |
| Qslow (liters/h) | 0.035 | 0.0435 (0.0287–0.0616) | 0.035b | NA |
| V3 (liters) | 69.2 | 92.5 (46.19–372.10) | 69.2b | NA |
| KA (h−1) | 1.16 | 1.06 (0.75–1.50) | 1.16b | NA |
| Vss (liters) | 122 | 146.85 (101.20–426.22) | 123.1 | 7.8 |
| BSV-CL | 51% | 66% (44%–236%) | ||
| BSV—V1 | 23% | 20.3% (5.8%–35%) | ||
| BSV—V2 | 20% | 17.5% (4.9%–27%) | ||
| IOV-F | 41% | 62% (35%–89%) | ||
| Residual error | 16% | 17% (15%–20%) | ||
a
Values for 95% confidence intervals were determined from the bootstrap (BS) parameter. Vss values represent the sum of V1 + V2 + V3 estimates. PopPK, population PK.
b
No BSV variability was estimated, so all subjects were assigned empirical Bayesian values that were equal to the population PK values for these parameters.