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Model-based simulations of rilpivirine at 25 mg QD (A), 50 mg QD (B), and 25 mg BID (C) in HIV-positive individuals. Solid lines, population median prediction (PI50%) from the model; shaded areas, 95% prediction intervals; dashed line, proposed target value of 50 ng/ml; dotted line, high concentration that could lead to a significant QTc prolongation.
