TABLE 2.
Pharmacokinetic parameters obtained in the final model with bootstrap analysis resultsa
| RPV parameter | Final population PK parameters |
Bootstrap resultb |
||
|---|---|---|---|---|
| Estimate (shrinkage [%]) | RSE (%) | Median | 95% CI | |
| CL/F (liters/h) | 11.7 | 2.8 | 11.7 | 10.9–12.5 |
| V/F (liters) | 401 | 14.1 | 393 | 291–525 |
| D1 (h) | 4 | 24.7 | 4 | 2.1–9.5 |
| IIV CL/F (%) | 33 (15) | 6. | 35 | 28–36 |
| Additive residual error (ng/ml) | 9.8 (30) | 13.6 | 9.6 | 7.3–13 |
| Proportional residual error (%) | 21.6 (30) | 7 | 21.2 | 17.6–24.2 |
a
Abbreviations: CL/F, mean apparent clearance; V/F, mean apparent volume of distribution; D1, mean absorption time; F, bioavailability; IIV, estimate of interindividual variability; RSE, relative standard error of the estimates defined as the standard error/estimate, with the standard error being directly retrieved from NONMEM.
b
Bootstrap results are for 2,000 samples.