TABLE 1.
EC50s of CR135, CR142, MAD28, and SQ129 in malaria parasites and human cells
| Parasite or human cell type | Avg EC50a ± SE of: |
|||
|---|---|---|---|---|
| CR135 | CR142 | MAD28 | SQ129 | |
| Dd2 (nM) | 10.2 ± 2.9 | 15.0 ± 4.6 | 267.5 ± 20.5 | 106.5 ± 13.1 |
| 3D7 (nM) | 12.3 ± 3.5 | 18.1 ± 3.7 | 312.4 ± 23.7 | 99.5 ± 10.2 |
| HEK293 (μM) | 1.45 ± 0.35 | 2.21 ± 0.42 | 1.83 ± 0.14 | 9.6 ± 0.45 |
a
The data shown are from three to five independent experiments. Note that concentrations are nanomolar for P. falciparum lines Dd2 and 3D7 but micromolar for HEK293 cells.