TABLE 5.

Simulated antibiotic dosing regimens and corresponding drug concentrations

Drug	Simulated dosing regimen	Concn (mg/liter)	Reference
Amikacin	15–20 mg/kg every 24 h	80	28
Aztreonam	6 g every 24 h (infused over 24 h)	18	29
Cefepime	2 g every 8 h	200	30
Doripenem	1 g every 8 h (infused over 4 h)	13	31
Imipenem	1 g every 6 h (infused over 0.5 h)	32	32
Levofloxacin	750 mg every 24 h	8	33
Meropenem	2 g every 8 h (infused over 3 h)	64	34
Piperacillin-tazobactam	4.5 g every 6 h (infused over 4 h)	75/15	35
Polymyxin B	30,000 IU/kg/day or at least 1 MU every 12 h	2	36
Rifampin	600 mg every 12 h	2	37
Tigecycline	100 mg every 12 h	2	13