TABLE 1.
Species distribution and percentage of isolates, overall and by species, in which the paradoxical effect of caspofungin, anidulafungin, micafungin, or any combination of the three was observed at any drug concentration
| Antifungal concentration (μg/ml) | % Isolates in which the paradoxical effect was observed fora: |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All species (n = 602)b |
C. tropicalis (n = 50) |
Other Candida spp. (n = 24)c |
C. albicans (n = 291) |
C. parapsilosis (n = 164) |
C. glabrata (n = 62) |
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| MYC | AND | CAS | MYC | AND | CAS | MYC | AND | CAS | MYC | AND | CAS | MYC | AND | CAS | MYC | AND | CAS | |
| 0.125 | 0 | 0.3 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0.3 | NA | NA | NA | NA | 0 | 0 | NA |
| 0.25 | 0.2 | 0.7 | 0.2 | 0 | 4 | 0 | 0 | 0 | 4.2 | 0 | 0.7 | 0 | NA | NA | NA | 0 | 0 | 0 |
| 0.5 | 2.3 | 1.8 | 1.2 | 18 | 14 | 6 | 8.3 | 4.2 | 12.5 | 0.3 | 1 | 0 | NA | NA | NA | 0 | 0 | 0 |
| 1 | 3.2 | 2.2 | 1.8 | 26 | 16 | 8 | 12.5 | 8.3 | 16.7 | 1 | 1 | 0.3 | NA | NA | NA | 0 | 0 | 0 |
| 2 | 3.7 | 4.8 | 5.6 | 30 | 36 | 32 | 12.5 | 8.3 | 29.2 | 1 | 3.1 | 1 | 0 | NA | 0 | 0 | 0 | 0 |
| 4 | 4 | 7.6 | 7.6 | 38 | 44 | 50 | 12.5 | 12.5 | 29.2 | 1.4 | 5.8 | 2.4 | 0 | 1.2 | 2.4 | 1.6 | 3.2 | 0 |
| 8 | 4 | 8.1 | 11.6 | 38 | 40 | 54 | 8.3 | 16.7 | 25 | 0.3 | 8.2 | 2.4 | 0.6 | 0 | 4.3 | 1.6 | 3.2 | 0 |
| Overall | 4.8 | 10.5 | 13.3 | 38 | 48 | 62 | 16.7 | 16.7 | 29.2 | 0.3 | 10.7 | 9.6 | 0.6 | 1.2 | 5.5 | 1.6 | 3.2 | 0 |
a
Statistically significant differences (P < 0.05) are shown in bold. MYC, micafungin; AND, anidulafungin; CAS, caspofungin; NA, not applicable.
b
C. krusei isolates (n = 11) are not shown because none of them showed paradoxical effect for any echinocandin.
c
C. guilliermondii (n = 8), C. dubliniensis (n = 5), C. lusitaniae (n = 5), C. kefyr (n = 2), C. fermentati (n = 1), C. inconspicua (n = 1), C. pelliculosa (n = 1), Kodamaea ohmeri (n = 1).