TABLE 4.
Mean pharmacokinetic parameters of omadacycline in rat plasma after a single 5 mg/kg i.v. dose or 90 mg/kg oral dose of 14C-omadacycline
| Parametera |
14C-Omadacycline value |
|
|---|---|---|
| 5 mg/kg i.v. dose (n = 3) | 90 mg/kg oral dose (n = 3) | |
| t1/2 (h) | 4.6 | 3.9 |
| Tmax (h) | 0.083 | 0.5 |
| Cmax (ng/ml) | 1,460.0 | 47.5 |
| AUClast (ng · h/ml) | 3,590.0 | 146.0 |
| AUC0–∞/dose ([ng · h/ml]/[mg/kg]) | 836 | 3.1 |
| AUC0–∞ (ng · h/ml) | 4,180.0 | 283.0 |
| CL (ml/h/kg) | 1,200.0 | |
| Vss (ml/kg) | 6,890.0 | |
| Absorption (%) | 2.93 | |
| Bioavailability (%) | 0.226 | |
a
AUClast, area under the concentration/time curve at last observation; AUC0–∞/dose, area under the concentration/time curve from 0 h to infinity adjusted for dose; AUC0–∞, area under the concentration/time curve from 0 h to infinity; CL, clearance; Cmax, peak concentration of drug in plasma; Tmax, time to peak concentration of drug in plasma; t1/2, half-life; Vss, volume of distribution (steady state).