Table 1.

Demographic and neuropsychological data.

	Baseline			Follow-up
	MCI (n = 80)	HC (n = 127)	P	MCI (n = 50)	HC (n = 60)	P
Age (years)	69.53 ± 7.43	68.88 ± 6.67	0.085	71.14 ± 7.21	71.27 ± 5.86	0.93
Gender (M/F)	47/40	65/70	0.354	28/22	28/32	0.33
Education (years)	11.83 ± 3.18	12.28 ± 2.99	0.178	11.79 ± 3.18	12.66 ± 2.95	0.10
Diabetic (Y/N)	12/75	20/115	0.832	7/43	12/48	0.43
Composite Z scores of each cognitive domain
General cognition	− 0.62 ± 1.05	0.39 ± 0.52	< 0.001	− 0.48 ± 1.37	0.35 ± 0.16	< 0.001
Episodic memory	− 0.75 ± 0.70	0.48 ± 0.50	< 0.001	− 0.73 ± 0.73	0.56 ± 0.46	< 0.001
Visuospatial function	− 0.40 ± 1.12	0.26 ± 0.82	< 0.001	− 0.42 ± 1.32	0.32 ± 0.50	< 0.001
Information processing speed	− 0.45 ± 0.75	0.29 ± 0.74	< 0.001	− 0.63 ± 0.92	0.33 ± 0.77	< 0.001
Executive function	− 0.45 ± 0.81	0.29 ± 0.81	< 0.001	− 0.55 ± 0.96	0.31 ± 0.57	< 0.001

Data was represented as mean ± SD. Details are shown in Table S1.