Table 2.
Set-based analysis reveals the cognitive significances of SNPs related to the pathway of brain insulin resistance.
| GENE | NSNP | NSIG | ISIG | EMP | SNPs | Cognition |
|---|---|---|---|---|---|---|
| AKT2 | 8 | 2 | 2 | 0.029 | rs41275750, rs33933140 | General cognition |
| PIK3CB | 1 | 1 | 1 | 0.003 | rs2305268 | Episodic memory |
| IGF1R | 23 | 6 | 1 | 0.02 | rs1815009 | Episodic memory |
| PIK3CD | 8 | 1 | 1 | 0.001 | rs72633865 | Execution |
| MTOR | 47 | 30 | 4 | 0.002 | rs4845988,rs3737611, rs17235612,rs7524202 | Execution |
| IDE | 7 | 1 | 1 | 0.026 | rs1887922 | Execution |
| AKT1S1 | 5 | 2 | 1 | 0.038 | rs3810268 | Execution |
| AKT1 | 15 | 6 | 2 | 0.01 | rs3803304, rs2494735 | Information processing speed |
NSNP: number of SNPs in set; NSIG: total number of SNPs below p-value 0.05 in the linear regression analysis; ISIG: number of significant SNPs also passing linkage disequilibrium-criterion; EMP, empirical set-based p-value; SNPs, list of single nucleotide polymorphisms.