Table 3.
Brain regions extracted from the genotype-by-MCI interactions.
| GENE | SNP | Allele | Peak MNI | Cluster size (mm3) | Peak F value | Brain region |
|---|---|---|---|---|---|---|
| IGF1R | rs1815009 | CT | − 51 − 57 48 | 7425 | 9.1 | LIPL |
| IDE | rs1887922 | CT | 42 33 39 | 6210 | 10.5 | RMFG |
| PIK3CB | rs2305268 | CT | 9 –60 − 45 | 10,017 | 9.0 | RcpCbm |
| − 36 − 12 − 33 | 13,689 | 9.2 | LHip/PHG | |||
| − 12 − 12 72 | 6750 | 7.1 | BPCL | |||
| AKT1 | rs3803304 | CG | 69 –36 27 | 6291 | 14.9 | RSTG |
| 21 51 18 | 6156 | 11.2 | RSFG | |||
| rs2494735 | TC | NA | ||||
| PI3KCD | rs72633865 | CG | 18–100 0 | 8667 | 14.5 | RIOG |
| MTOR | rs17235612 | CT | 9 –48 − 54 | 11,907 | 19.6 | RcpCbm |
| 69 –30 21 | 14,067 | 28.4 | RINS | |||
| rs4845988 | AG | − 57 − 6 − 18 | 15,417 | 21.4 | LMTG | |
| rs3737611 | AG | NA | ||||
| rs7524202 | TC | NA | ||||
| AKT1S1 | rs3810268 | CT | NA | |||
| AKT2 | rs33933140 | AG | − 15 6 –30 | 8883 | 8.5 | LSTG |
| rs41275750 | CG | − 6 57 18 | 6237 | 9.6 | LMFG/SFG |
All of these regions survived the Monte Carlo correction. LIPL, left inferior parietal lobule; R/LMFG, right/left middle frontal gyrus; RcpCbm, right cerebellum posterior lobe; LHip/PHG, left Hippocampus/ParaHippocampal; BPCL, bilateral Paracentral Lobule; R/LSTG, right/left superior temporal gyrus; R/LSFG, right/left superior frontal gyrus; RIOG, right inferior occipital gyrus; RINS, right insula; LMTG, left middle temporal gyrus.