Table 1.
Effect of perfusion of isolated rat hearts with oleuropein before induction of ischemic – reperfusion injury on myocardial function parameters.
| Base |
PO5 |
Ie |
R5 |
R10 |
R30 |
R60 |
R90 |
|
|---|---|---|---|---|---|---|---|---|
| HR | ||||||||
| Con-P | 265 ± 11 | 264 ± 8 | 0 ± 0 | 207 ± 28 | 239 ± 14 | 226 ± 16 | 222 ± 9 | 217 ± 14 |
| O10 | 263 ± 18 | 263 ± 18 | 0 ± 0 | 218 ± 13 | 231 ± 9 | 233 ± 7 | 233 ± 8 | 223 ± 7 |
| O50 | 275 ± 10 | 281 ± 9 | 0 ± 0 | 233 ± 15 | 230 ± 16 | 252 ± 14 | 245 ± 17 | 246 ± 16 |
| LVEDP | ||||||||
| Con-P | 5.3 ± 0.3 | 5.8 ± 0.3 | 26 ± 2.8 | 61 ± 5.2 | 59 ± 5.6 | 53 ± 5.1 | 50 ± 3.5 | 44 ± 2.4 |
| O10 | 6.4 ± 0.4 | 6 ± 0.5 | 18 ± 4.2 | 41 ± 3.9 b | 35 ± 3.3 b | 31 ± 3 b | 30 ± 3.9 | 29 ± 3.9 b |
| O50 | 4.4 ± 0.8 | 4.2 ± 0.8 | 20 ± 5.8 | 35 ± 5.9 b | 30 ± 5.5 b | 39 ± 4.6 b | 35 ± 6.5 b | 32 ± 5.9 b |
| LVDP | ||||||||
| Con-P | 101 ± 2.9 | 101 ± 83 | 0 ± 0 | 66 ± 11 | 49 ± 4.9 | 47 ± 6.6 | 44 ± 4.9 | 66 ± 11 |
| O10 | 95 ± 3.7 | 95 ± 5.2 | 0 ± 0 | 70 ± 9.8 | 67 ± 6 | 65 ± 6.7 a | 63 ± 607 a | 60 ± 5 a |
| O50 | 97 ± 8.7 | 99 ± 9 | 0 ± 0 | 64 ± 8.5 | 58 ± 8.5 | 54 ± 4.6 | 54 ± 7.9 a | 52 ± 7.6 a |
| max dp/dt | ||||||||
| Con-P | 3743 ± 338 | 3846 ± 291 | 0 ± 0 | 2565 ± 370 | 2295 ± 172 | 2199 ± 239 | 1947 ± 154 | 1922 ± 365 |
| O10 | 3922 ± 267 | 3782 ± 301 | 0 ± 0 | 3420 ± 413 | 3144 ± 236 a | 3112 ± 200 a | 3062 ± 263 a | 2716 ± 250 |
| O50 | 3548 ± 138 | 3616 ± 138 | 0 ± 0 | 2863 ± 226 | 3211 ± 272 a | 3013 ± 189 | 2665 ± 204 a | 2268 ± 192 |
| min dp/dt | ||||||||
| Con-P | −2972 ± 110 | −3013 ± 104 | 0 ± 0 | −2045 ± 164 | −1885 ± 101 | −1906 ± 129 | 1783 ± 116 | −1551 ± 280 |
| O10 | −2859 ± 224 | −3190 ± 234 | 0 ± 0 | −2607 ± 231a | 2545 ± 239 a | 2376 ± 201 a | −2376 ± 214 a | −2167 ± 174 a |
| O50 | −2920 ± 149 | −2827 ± 131 | 0 ± 0 | −2657 ± 288 a | −2366 ± 204 a | −2103 ± 227 | −2174 ± 238 a | −2034 ± 188 a |
| CF | ||||||||
| Con-P | 11.8 ± 0.5 | 11.8 ± 0.4 | 0 ± 0 | 7 ± 0.7 | 6.7 ± 0.6 | 6.3 ± 0.7 | 5.3 ± 0.8 | 4.6 ± 0.9 |
| O10 | 12 ± 0.8 | 12.3 ± 0.4 | 0 ± 0 | 10.1 ± 1 a | 9.3 ± 0.9 a | 8.5 ± 0.9 a | 8 ± 0.8 a | 7.3 ± 0.7 a |
| O50 | 11.9 ± 0.7 | 12.3 ± 0.7 | 0 ± 0 | 10.2 ± 1.2 b | 8.7 ± 0.8 a | 9.3 ± 1.2 a | 8.6 ± 1.1 a | 7.8 ± 1.1 a |
Data shown that as Mean ± SEM.
HR, heart rate; LVEDP, left ventricular end diastolic pressure; LVDP, left ventricular developed pressure and CF, coronary flow (G). Con-P, pre-treatment control group; O10-P and O50-P mean groups that the hearts were received 10 and 50 μg/g heart oleuropein for 5 min before ischemia, respectively. PO5 means 5 min after oleuropein infusion, respectively. I and R mean ischemic and reperfusion times, respectively. a; p < 0.05 and b; p < 0.01 vs control group.