Table 3.
Histopathological characteristics of previously reported cases
| Author (year) | Number of patients | Background mucosa | Depth (M:SM) (µm, average) | Lymphatic invasion (+:-) | Venous invasion (+:-) | MUC2 (+:-) | MUC5AC (+:-) | MUC6 (+:-) | CD10 (+:-) | Overexpression of p53 (+:-) | Ki-67 LI (%, average) |
| Tsukamoto et al[4] (2007) | 1 | ND | M | (-) | (-) | ND | ND | (+) | ND | ND | 7.9 |
| Ueyama et al[5] (2010) | 10 | Normal: 7 | 1:9 | 0:10 | 0:10 | 0:10 | 1:9 | 10:0 | 0:10 | 0:10 | 3.6 |
| Metaplasia: 1 | 844 (150 to 4000) | ||||||||||
| ND: 2 | |||||||||||
| Fukatsu et al[6] (2011) | 1 | ND | SM, 100 | (-) | (-) | ND | (-) | (+) | ND | ND | ND |
| Park et al[8] (2012) | 3 | Metaplasia: 2 | 1:2 | 0:3 | 0:3 | 0:3 | 3:0 | 3:0 | 0:3 | ND | ND |
| Gastritis: 1 | |||||||||||
| Singhi et al[9] (2012) | 10 | Normal: 7 | 10:0 | 0:10 | 0:10 | 0:3 | 0:10 | 10:0 | ND | 0:9 | 2.6 |
| Gastritis: 3 | ND: 1 | (0.2-10) | |||||||||
| Chen et al[10] (2012) | 1 | Normal | SM (Details unknown) | (-) | (-) | (-) | (-) | (-) | (-) | (-) | 3.8 |
| Abe et al[11] (2013) | 1 | Normal | SM (Details unknown) | (-) | (-) | (-) | (-) | (-) | (-) | (-) | 1.9 |
| Ueyama et al[12] (2014) | 10 | Normal: 9 | 5:5 | 1:9 | 0:10 | 0:10 | 4:6 | 10:0 | 2:8 | 0:10 | 8.6 (1-20) |
| Gastritis: 1 | 360 (100 to 1200) | ||||||||||
| Miyazawa et al[13] (2015) | 5 | Normal: 4 | 0:5 | 1:4 | 0:5 | 0:5 | 0:5 | 5:0 | ND | 0:5 | Very low: 5 (Details unknown) |
| Gastritis: 1 | 620 (80 to 1230) | ||||||||||
| Parikh et al[14] (2015) | 1 | ND | SM (Details unknown) | (-) | (-) | ND | ND | ND | ND | ND | ND |
| Kato et al[15] (2015) | 1 | Normal | SM, 300 | (-) | (-) | ND | ND | (+) | ND | ND | ND |
| Fujii et al[16] (2015) | 1 | Normal | SM, 300 | (-) | (-) | ND | (-) | (+) | ND | ND | ND |
LI: Labeling index; M: Mucosal; SM: Submucosal; ND: Not described.