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. 2016 Dec 28;22(48):10545–10556. doi: 10.3748/wjg.v22.i48.10545

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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Effects of nitric oxide synthase inhibitors on basal nitric oxide release in renal artery. Contractions induced by L-NAME (n = 8) and ADMA (n = 8) on rings of rat renal artery with endothelium from Sham, PPVL, and BDL groups in the absence and in the presence of L-arginine (L-arg, 10^-3 mol/L, n = 6). Contractions were determined after evoking submaximal tone with 10^-7-3 × 10^-7 mol/L norepinephrine. PPVL: Pre-hepatic portal hypertension; BDL: Bile duct ligation; ADMA: Asymmetric dimethylarginine; L-NAME: N^G-nitro-L-arginine methyl ester.