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. 2016 Dec 28;22(48):10545–10556. doi: 10.3748/wjg.v22.i48.10545

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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Effects of nitric oxide synthase inhibitors on acetylcholine-induced relaxation in renal artery. A: Concentration-response curves to acetylcholine on rings of rat renal artery from Sham, PPVL, and BDL groups in artery rings with endothelium (n = 8) and without endothelium (n = 6) and in artery rings with endothelium in the presence of L-NAME (3 × 10^-4 mol/L; n = 8) or ADMA (3 × 10^-4 mol/L; n = 8). Relaxation is expressed as a percentage of the contraction in response to norepinephrine; B: Difference between the areas under curves (AUCs) from artery rings with endothelium (Control) and treated with L-NAME or ADMA. ^aP < 0.05 vs L-NAME treated group and ^cP < 0.05 vs Sham and PPVL groups treated with ADMA. PPVL: Pre-hepatic portal hypertension; BDL: Bile duct ligation.