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. 2016 Dec 21;8(12):337. doi: 10.3390/v8120337

Figure 1.

Figure 1

Cryo-electron microscopy (cryoEM) structural analysis of adenovirus–integrin interaction. (A) Full human adenovirus (HAdV)-A12/soluble-αvβ5-integrin structure viewed along a two-fold icosahedral axis. The icosahedral capsid is shown in blue, the proximal integrin density in gold, and the distal, more diffuse integrin density in red; (B) Enlarged side view of the vertex region with the fiber shaft in green. Scale bars, 100 Å; (C) Model of an extended conformation of the soluble form of αvβ5 integrin with Fos/Jun dimerization domains used for the cryoEM study. The bound RGD (arg-gly-asp) peptide is shown in green; (D) The cryoEM HAdV-A12/αvβ5 integrin density (mesh) docked with four copies of the integrin ectodomain in an extended conformation. Reprinted with permission from [47]. Copyright © American Society for Microbiology, Journal of Virology, 83, 2009, 11491–11051, doi:10.1128/JVI.01214-09.